This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
- Regulation of heart rate
- Regulation of membrane depolarization
- ER to Golgi vesicle-mediated transport
- Protein transport
- Protein exit from endoplasmic reticulum
- Brugada syndrome
- Sick sinus syndrome
- Cardiac arrhythmia
- Right bundle branch block
- Long qt syndrome 1
