Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

  • Ion transport
  • Sodium ion transport
  • Nervous system development
  • Positive regulation of heart rate
  • Positive regulation of sodium ion transport
  • Brugada syndrome 7
  • Brugada syndrome
  • Familial atrial fibrillation
  • Atrial fibrillation
  • Right bundle branch block
  • Brugada Syndrome
  • Familial Atrial Fibrillation
  • Cardiomuscular
  • General Arrhythmia

Based on Ayass Bioscience, LLC Data Analysis

Structure of Sodium channel subunit beta-3. Ismaïl Jarmouni.

Gene Location

HM-VUS Prevalence

% 0.102145045965271

Ratio of samples with at least 1 High/Med VUS variant (Computed from Ayass Bioscience Samples)

High/Med VUS Variants

G=0.000203(51/251474,GnomAD_exome)
G=0.000271(34/125568,TOPMED)
G=0.000173(21/121380,ExAC)
G=0.00032(10/31386,GnomAD)
G=0.00027(3/11176,ALFAProject)
G=0.0007(3/4480,Estonian)
G=0.0005(2/3854,ALSPAC)
G=0.0000(0/3708,TWINSUK)
G=0.001(1/998,GoNL)
G=0.004(2/534,MGP)