This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

  • Signal transduction
  • Ras protein signal transduction
  • Fibroblast growth factor receptor signaling pathway
  • Regulation of phosphoprotein phosphatase activity
  • Positive regulation of Ras protein signal transduction
  • Noonan syndrome-like disorder with loose anagen hair 1
  • Noonan syndrome 3
  • Rasopathy
  • Noonan syndrome 1
  • Loose anagen hair syndrome

Gene Location