This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
- Signal transduction
- Ras protein signal transduction
- Fibroblast growth factor receptor signaling pathway
- Regulation of phosphoprotein phosphatase activity
- Positive regulation of Ras protein signal transduction
- Noonan syndrome-like disorder with loose anagen hair 1
- Noonan syndrome 3
- Rasopathy
- Noonan syndrome 1
- Loose anagen hair syndrome
Gene Location
