This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Tumor type associations:

  • Endometrial
  • Prostate
  • Enables protein binding
  • Enables ubiquitin protein ligase binding
  • Located in nucleus
  • Located in nucleoplasm
  • Is active in cytoplasm
  • Located in nuclear speck
  • Part of Cul3-RING ubiquitin ligase complex
  • Involved in protein polyubiquitination
  • Protein ubiquitination
  • Involved in regulation of proteolysis
  • Involved in proteasome-mediated ubiquitin-dependent protein catabolic process
  • Nabais Sa-de Vries syndrome, type 1
  • Nabais Sa-de Vries syndrome, type 2

SPOP localizations – Subcellular Localization Database

EmwStructure of the SPOP protein. Based on PyMOL rendering of PDB 2cr2.

Gene Location