This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Tumor type associations:
- Endometrial
- Prostate
- Enables protein binding
- Enables ubiquitin protein ligase binding
- Located in nucleus
- Located in nucleoplasm
- Is active in cytoplasm
- Located in nuclear speck
- Part of Cul3-RING ubiquitin ligase complex
- Involved in protein polyubiquitination
- Protein ubiquitination
- Involved in regulation of proteolysis
- Involved in proteasome-mediated ubiquitin-dependent protein catabolic process
- Nabais Sa-de Vries syndrome, type 1
- Nabais Sa-de Vries syndrome, type 2
SPOP localizations – Subcellular Localization Database
Emw. Structure of the SPOP protein. Based on PyMOL rendering of PDB 2cr2.
Gene Location
