This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

  • Negative regulation of transcription by RNA polymerase II
  • Regulation of transcription, DNA-templated
  • Lipid metabolic process
  • Steroid metabolic process
  • Cholesterol metabolic process

  • Atherosclerosis susceptibility
  • Avascular necrosis
  • Familial hypercholesterolemia
  • Non-alcoholic fatty liver disease
  • Fatty liver disease

SREBF2 (sterol regulatory element binding transcription factor 2) – BioGPS

Interacting Proteins for SREBF2 Gene – String

Emw. Structure of the SREBF2 protein. Based on PyMOL rendering of PDB 1ukl.

Gene Location