Over 150 Genomic Regions Contain Variations Predisposing Individuals to Immune-Mediated Disease

Identification of these Disease-Causing Pathways Opens a Good Ground for Diagnostic and Therapeutic Intervention of Immune-Meditated Disease

Immune dysregulation can affect any organ system and result in developing Immune-Mediated Disease (IMID) – a group of seemingly unconnected conditions, but share common inflammatory pathways, such as Ankylosing Spondylitis (AS), Type 1 Diabetes, Multiple Sclerosis, Rheumatoid Arthritis (RA), Crohn’s Disease (CD), Iritis, Psoriasis, Inflammatory Bowel Disease, and many more.

Proteins Encoded in Genomic Regions associated with Immune-Mediated Disease are physically bound to each other (protein-protein interactions), indicating connections between regions associated to IMID, pointing to a common set of underlying molecular processes that can predict a person’s risk of IMID.